BIOPROCESS ENGINEERING PRINCIPLES (FUNDAMENTOS DE INGENIERIA DE BIOPROCESOS)

Recent developments in genetic and molecular biology have excited world-wide interest in biotechnology. The ability to manipulate DNA has already changed our perceptions of medicine, agriculture and environmental management.
Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services.
Many a student has been enticed by the promise ofbiotechnology and the excitement of being near the cutting edge of scientific advancement. However, the value of biotechnology is more likely to be assessed by business, government and consumers
alike in terms of commercial applications, impact on the marketplace and financial success. Graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the complete picture; bringing about the full benefits of biotechnology requires substantial manufacturing capability involving large-scale processing of biological material. For the most part, chemical engineers have assumed the responsibility for bioprocess development. However, increasingly, biotechnologists are being employed by companies to work in co-operation with
biochemical engineers to achieve pragmatic commercial goals.
Yet, while aspects of biochemistry, microbiology and molecular genetics have for many years been included in chemical-engineering curricula, there has been relatively little attempt to teach biotechnologists even those qualitative aspects of engineering applicable to process design.

Table of Contents
Preface
Ch. 1 Bioprocess Development: An Interdisciplinary Challenge 3
Ch. 2 Introduction to Engineering Calculations 9
Ch. 3 Presentation and Analysis of Data 27
Ch. 4 Material Balances 51
Ch. 5 Energy Balances 86
Ch. 6 Unsteady-State Material and Energy Balances 110
Ch. 7 Fluid Flow and Mixing 129
Ch. 8 Heat Transfer 164
Ch. 9 Mass Transfer 190
Ch. 10 Unit Operations 218
Ch. 11 Homogeneous Reactions 257
Ch. 12 Heterogeneous Reactions 297
Ch. 13 Reactor Engineering 333
Appendices 393
Appendix A Conversion Factors 395
Appendix B Physical and Chemical Property Data 398
Appendix C Steam Tables 408
Appendix D Mathematical Rules 413
Appendix E List of Symbols 417
Index

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